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Epilim is contraindicated in the following situations: In pregnancy unless there is no suitable alternative treatment (see Warnings, Precautions and Use in Pregnancy & Lactation).
In women of childbearing potential unless the conditions of Pregnancy Prevention Programme are fulfilled (see Warnings, Precautions and Use in Pregnancy & Lactation).
Active liver disease, or personal or family history of severe hepatic dysfunction, especially drug-related.
Patients with known urea cycle disorders (see Precautions).
Hypersensitivity to sodium valproate or any other excipients.
Porphyria.
Patients known to have mitochondrial disorders caused by mutations in the nuclear gene encoding the mitochondrial enzyme polymerase γ (POLG), e.g. Alpers-Huttenlocher Syndrome, and in children under two years of age who are suspected of having a POLG-related disorder (see Special warnings under Precautions).
